Enhanced Activity and Substrate Specificity by Site‐Directed Mutagenesis for the P450 119 Peroxygenase Catalyzed Sulfoxidation of Thioanisole

Abstract P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert‐butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min−1 and 196 min−1 respectively. Several mutants were designed to improve the pero...

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Detalhes bibliográficos

Principais autores:	Xiaoyao Wei, Dr. Chun Zhang, Dr. Xiaowei Gao, Yanping Gao, Ya Yang, Dr. Kai Guo, Xi Du, Lin Pu, Prof. Dr. Qin Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley-VCH 2019-08-01
coleção:	ChemistryOpen
Assuntos:	P450 peroxygenase site-directed mutagenesis sulfoxidation reactions turnover rate catalytic mechanism
Acesso em linha:	https://doi.org/10.1002/open.201900157
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