Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity.

Doxorubicin (DOX) is a commonly used life-saving antineoplastic agent that also causes dose-dependent cardiotoxicity. Because ATP is absolutely required to sustain normal cardiac contractile function and because impaired ATP synthesis through creatine kinase (CK), the primary myocardial energy reser...

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Detalhes bibliográficos

Principais autores:	Ashish Gupta, Cory Rohlfsen, Michelle K Leppo, Vadappuram P Chacko, Yibin Wang, Charles Steenbergen, Robert G Weiss
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2013-01-01
Colecção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3788056?pdf=render
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