Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity.

Doxorubicin (DOX) is a commonly used life-saving antineoplastic agent that also causes dose-dependent cardiotoxicity. Because ATP is absolutely required to sustain normal cardiac contractile function and because impaired ATP synthesis through creatine kinase (CK), the primary myocardial energy reser...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Ashish Gupta, Cory Rohlfsen, Michelle K Leppo, Vadappuram P Chacko, Yibin Wang, Charles Steenbergen, Robert G Weiss
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Public Library of Science (PLoS) 2013-01-01
Sarja:	PLoS ONE
Linkit:	http://europepmc.org/articles/PMC3788056?pdf=render
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