Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis. Statins reduce plasma cholesterol levels, but whether this is actually caused by inhibition of de novo cholesterol synthesis has not been clearly established. Using three different statins, we...

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Autors principals:	Marleen Schonewille, Jan Freark de Boer, Laura Mele, Henk Wolters, Vincent W. Bloks, Justina C. Wolters, Jan A. Kuivenhoven, Uwe J.F. Tietge, Gemma Brufau, Albert K. Groen
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2016-08-01
Col·lecció:	Journal of Lipid Research
Matèries:	cholesterol/absorption cholesterol/biosynthesis liver intestine biliary cholesterol transintestinal cholesterol excretion
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0022227520352172
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