Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine–Thiosemicarbazone Derivatives

In this study, we report the synthesis of twenty new acridine–thiosemicarbazone derivatives and their antiproliferative activities. Mechanisms of action such as the inhibition of topoisomerase IIα and the interaction with DNA have been studied for some of the most active derivatives by means of both...

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Autori principali:	Gleyton Sousa, Maria C. F. de Almeida, Lucas L. Lócio, Vanda L. dos Santos, Daniel P. Bezerra, Valdenizia R. Silva, Sinara M. V. de Almeida, Alice Simon, Thiago da S. Honório, Lucio M. Cabral, Rosane N. Castro, Ricardo O. de Moura, Arthur E. Kümmerle
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-09-01
Serie:	Pharmaceuticals
Soggetti:	acridine–thiosemicarbazone antiproliferative topoisomerase IIα
Accesso online:	https://www.mdpi.com/1424-8247/15/9/1098
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