Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine–Thiosemicarbazone Derivatives

In this study, we report the synthesis of twenty new acridine–thiosemicarbazone derivatives and their antiproliferative activities. Mechanisms of action such as the inhibition of topoisomerase IIα and the interaction with DNA have been studied for some of the most active derivatives by means of both...

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主要な著者:	Gleyton Sousa, Maria C. F. de Almeida, Lucas L. Lócio, Vanda L. dos Santos, Daniel P. Bezerra, Valdenizia R. Silva, Sinara M. V. de Almeida, Alice Simon, Thiago da S. Honório, Lucio M. Cabral, Rosane N. Castro, Ricardo O. de Moura, Arthur E. Kümmerle
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2022-09-01
シリーズ:	Pharmaceuticals
主題:	acridine–thiosemicarbazone antiproliferative topoisomerase IIα
オンライン･アクセス:	https://www.mdpi.com/1424-8247/15/9/1098
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