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Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods

Abstract Human endocrine cell differentiation and islet morphogenesis play critical roles in determining islet cell mass and function, but the events and timeline of these processes are incompletely defined. To better understand early human islet cell development and maturation, we collected 123 ped...

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Autori principali: Diane C. Saunders, Fan Feng, Alexander L. Hopkirk, Kristie I. Aamodt, Nathaniel Hart, Fong Cheng Pan, Conrad V. Reihsmann, Nike Izmaylov, Shaojun Mei, Brandon A. Sherrod, Corey Davis, Nongyao Nonpanya, Yasminye D. Pettway, Keval P. Patel, Kai S. Lee, Jeff Duryea, Rachana Haliyur, Radhika Aramandla, Heather Durai, Greg Poffenberger, Alexandra Martin, Amanda L. Posgai, Irina Kusmartseva, Maria L. Beery, Mingder Yang, Ke Xu, Hakmook Kang, Dale L. Greiner, Leonard D. Shultz, Jean-Philippe Cartailler, Rita Bottino, Mark A. Atkinson, Christopher V. E. Wright, Alvin C. Powers, Marcela Brissova
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2026-06-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-026-73854-y
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