PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. The viral Tax oncoprotein is critically involved in both HTLV-1-replication and T-cell proliferation, a prerequisite t...

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Главные авторы:	Eléonore Pérès, Juliana Blin, Emiliano P Ricci, Maria Artesi, Vincent Hahaut, Anne Van den Broeke, Antoine Corbin, Louis Gazzolo, Lee Ratner, Pierre Jalinot, Madeleine Duc Dodon
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2018-03-01
Серии:	PLoS Pathogens
Online-ссылка:	http://europepmc.org/articles/PMC5882172?pdf=render
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PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.

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