Increasing Gene Editing Efficiency via CRISPR/Cas9- or Cas12a-Mediated Knock-In in Primary Human T Cells

T lymphocytes represent a promising target for genome editing. They are primarily modified to recognize and kill tumor cells or to withstand HIV infection. In most studies, T cell genome editing is performed using the CRISPR/Cas technology. Although this technology is easily programmable and widely...

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Hlavní autoři:	Natalia Kruglova, Mikhail Shepelev
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2024-01-01
Edice:	Biomedicines
Témata:	CRISPR/Cas genome editing primary T cells knock-in HDR CAR T
On-line přístup:	https://www.mdpi.com/2227-9059/12/1/119
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