RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres
Abstract Telomere repeat-containing RNA (TERRA) is transcribed at telomeres and forms RNA–DNA hybrids. In budding yeast, the presence of RNA–DNA hybrids at short telomeres promotes homology-directed repair (HDR) and prevents accelerated replicative senescence. RNA–DNA hybrids at telomeres have also...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Nature
2025-05-01
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| coleção: | EMBO Reports |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1038/s44319-025-00469-7 |
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