RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres

Abstract Telomere repeat-containing RNA (TERRA) is transcribed at telomeres and forms RNA–DNA hybrids. In budding yeast, the presence of RNA–DNA hybrids at short telomeres promotes homology-directed repair (HDR) and prevents accelerated replicative senescence. RNA–DNA hybrids at telomeres have also...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Fabio Bento, Matteo Longaretti, Vanessa Borges Pires, Arianna Lockhart, Brian Luke
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Springer Nature 2025-05-01
Цуврал:	EMBO Reports
Нөхцлүүд:	RNA–DNA Hybrid R-loop RNase H1 Telomere Senescence
Онлайн хандалт:	https://doi.org/10.1038/s44319-025-00469-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!