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Improved Pharmacokinetic Feasibilities of Mirabegron-1,2-Ethanedisulfonic Acid, Mirabegron-1,5-Naphthalenedisulfonic Acid, and Mirabegron-L-Pyroglutamic Acid as Co-Amorphous Dispersions in Rats and Mice

Mirabegron (MBR) is a β<sub>3</sub>-adrenoceptor agonist used for treating overactive bladder syndrome. Due to its poor solubility and low bioavailability (<i>F</i>), the development of novel MBR formulations has garnered increasing attention. Recently, co-amorphous dispersions of MBR, such as MBR-1...

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Principais autores: Seo-Yeon Kim, Byung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung, Young Hee Choi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-09-01
coleção:Pharmaceutics
Assuntos:
mirabegron
co-amorphous dispersion
pharmacokinetics
bioavailability
tissue distribution
Acesso em linha:https://www.mdpi.com/1999-4923/15/9/2277
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