Biallelic and gene-wide genomic substitution for endogenous intron and retroelement mutagenesis in human cells
Functional annotation of the vast noncoding landscape of the diploid human genome still remains a major challenge of genomic research. Here the authors present a scarless, biallelic, and 100 kb-scale mutagenesis in human cells that uncovers functional significances of endogenous introns and retrotra...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2022-07-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-022-31982-1 |
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