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High throughput screening for compounds to the orphan nuclear receptor NR2F6

NR2F6 is considered an orphan nuclear receptor since its endogenous ligand has yet to be identified. Recently, NR2F6 has emerged as a novel cancer therapeutic target. NR2F6 has been demonstrated to be upregulated or overexpressed in several cancers. Importantly, Nr2f6−/− mice spontaneously reject tu...

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Detalhes bibliográficos
Principais autores: Emery Smith, Sean Campbell, Adrianna N. Wilson, Justin Shumate, Pierre Baillargeon, Louis Scampavia, Theodore M. Kamenecka, Timothy P. Spicer, Laura A. Solt
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-06-01
coleção:SLAS Discovery
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Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2472555222125517
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