High throughput screening for compounds to the orphan nuclear receptor NR2F6

NR2F6 is considered an orphan nuclear receptor since its endogenous ligand has yet to be identified. Recently, NR2F6 has emerged as a novel cancer therapeutic target. NR2F6 has been demonstrated to be upregulated or overexpressed in several cancers. Importantly, Nr2f6−/− mice spontaneously reject tu...

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Bibliografiske detaljer

Principais autores:	Emery Smith, Sean Campbell, Adrianna N. Wilson, Justin Shumate, Pierre Baillargeon, Louis Scampavia, Theodore M. Kamenecka, Timothy P. Spicer, Laura A. Solt
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2022-06-01
Serier:	SLAS Discovery
Fag:	NR2F6 Nuclear receptor Immuno-oncology drug discovery High-throughput screening (HTS) Cancer
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2472555222125517
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