Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression

Abstract Background Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles in head and neck squamous cell carcinoma (HNSCC) re...

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Bibliografische Detailangaben

Hauptverfasser:	Jie Chen, Kang Li, Jianwen Chen, Xiaochen Wang, Rongsong Ling, Maosheng Cheng, Zhi Chen, Fangfang Chen, Qianting He, Shuai Li, Caihua Zhang, Yizhou Jiang, Qianming Chen, Anxun Wang, Demeng Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2022-03-01
Schriftenreihe:	Cancer Communications
Schlagworte:	head and neck squamous cell carcinoma m7G modification metastasis METTL1 microenvironment PI3K/AKT/mTOR signaling
Online-Zugang:	https://doi.org/10.1002/cac2.12273
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