Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging
Abstract Cellular senescence is characterized by a decrease in protein synthesis, although the underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) frequently influence tRNA activity, which is crucial for translation. We describe how tRNA N7-methylguanosine (m7G46...
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| Principais autores: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2024-07-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-024-49796-8 |
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