Computational exploration of Withania coagulans-derived natural inhibitors targeting HMG-CoA reductase: A pharmacokinetic, docking and molecular dynamics study for cholesterol regulation in Mus musculus
Background: Hypercholesterolemia is a major modifiable risk factor for cardiovascular disease, largely driven by excessive activity of 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), the rate-limiting enzyme in cholesterol biosynthesis. Although statins are effective inhibitors of this enzyme, the...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
University of Karachi
2026-01-01
|
| Schriftenreihe: | Pakistan Journal of Pharmaceutical Sciences |
| Online-Zugang: | https://pjps.pk/single-article?id=cmr823p16005t5mbrgtl0gdlu |
| Tags: |
Keine Tags, Fügen Sie das erste Tag hinzu!
|