Computational exploration of Withania coagulans-derived natural inhibitors targeting HMG-CoA reductase: A pharmacokinetic, docking and molecular dynamics study for cholesterol regulation in Mus musculus
Background: Hypercholesterolemia is a major modifiable risk factor for cardiovascular disease, largely driven by excessive activity of 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), the rate-limiting enzyme in cholesterol biosynthesis. Although statins are effective inhibitors of this enzyme, the...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
University of Karachi
2026-01-01
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| سلاسل: | Pakistan Journal of Pharmaceutical Sciences |
| الوصول للمادة أونلاين: | https://pjps.pk/single-article?id=cmr823p16005t5mbrgtl0gdlu |
| الوسوم: |
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