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Determining the Bordetella LPS structural features that influence TLR4 downstream signaling

Upon recognizing bacterial lipopolysaccharide (LPS), human TLR4 initiates two distinct signaling pathways: the MyD88 pathway from the cell surface or the TRIF pathway following endocytosis. While the first is associated with strong pro-inflammatory responses, the latter is linked to dendritic cell m...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Kiruthika Manivannan, Yasmine Fathy Mohamed, Rachel C. Fernandez
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2025-02-01
Rangatū:Frontiers in Microbiology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1540534/full
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