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The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.

Loss of Werner syndrome helicase-exonuclease (WRN) or of its homolog Bloom syndrome helicase (BLM) results in different inherited disorders. Whereas Werner syndrome is characterized by premature onset of aging and age-associated diseases, Bloom syndrome involves developmental abnormalities and incre...

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Detalhes bibliográficos
Principais autores: Ashwini Kamath-Loeb, Lawrence A Loeb, Michael Fry
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
coleção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3260238?pdf=render
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