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Tumour location and mismatch repair status impact gene expression profiles associated with lymph node metastases in T1 colon cancers

Abstract Accurate identification of which patients with early (T1) colon cancer (CC) have lymph node metastases (LNM) is a major challenge. Current strategies have limited accuracy, resulting in overtreatment of > 80% of patients. Whilst gene expression profiles (GEPs) have shown promise in identify...

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Principais autores: Anders L. Ebbehøj, Lars N. Jørgensen, Deepthi Chiranth, Linea C. Melchior, Thomas Litman, Peter-Martin Krarup, Henry G. Smith
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2026-05-01
Series:Scientific Reports
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Acceso en liña:https://doi.org/10.1038/s41598-026-52722-1
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