Tumour location and mismatch repair status impact gene expression profiles associated with lymph node metastases in T1 colon cancers

Abstract Accurate identification of which patients with early (T1) colon cancer (CC) have lymph node metastases (LNM) is a major challenge. Current strategies have limited accuracy, resulting in overtreatment of > 80% of patients. Whilst gene expression profiles (GEPs) have shown promise in identify...

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Autori principali:	Anders L. Ebbehøj, Lars N. Jørgensen, Deepthi Chiranth, Linea C. Melchior, Thomas Litman, Peter-Martin Krarup, Henry G. Smith
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-05-01
Serie:	Scientific Reports
Soggetti:	Colon cancer Lymph node metastases Gene expression profiles
Accesso online:	https://doi.org/10.1038/s41598-026-52722-1
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