Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain

Tissue-clearing and labeling techniques have revolutionized brain-wide imaging and analysis, yet their application to clinical formalin-fixed paraffin-embedded (FFPE) blocks remains challenging. We introduce HIF-Clear, a novel method for efficiently clearing and labeling centimeter-thick FFPE specim...

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Autors principals:	Ya-Hui Lin, Li-Wen Wang, Yen-Hui Chen, Yi-Chieh Chan, Shang-Hsiu Hu, Sheng-Yan Wu, Chi-Shiun Chiang, Guan-Jie Huang, Shang-Da Yang, Shi-Wei Chu, Kuo-Chuan Wang, Chin-Hsien Lin, Pei-Hsin Huang, Hwai-Jong Cheng, Bi-Chang Chen, Li-An Chu
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2024-05-01
Col·lecció:	eLife
Matèries:	tissue clearing multiplexed staining FFPE archived tissues whole mouse brain imaging whole brain analysis
Accés en línia:	https://elifesciences.org/articles/93212
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