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A Broad-Spectrum Antiviral Molecule, Protoporphyrin IX, Acts as a Moderator of HIV-1 Capsid Assembly by Targeting the Capsid Hexamer

ABSTRACT The capsid protein (CA), an essential component of human immunodeficiency virus type 1 (HIV-1), represents an appealing target for antivirals. Small molecules targeting the CAI-binding cavity in the C-terminal domain of HIV-1 CA (CA CTD) confer potent antiviral activities. In this study, we...

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Principais autores: Da-Wei Zhang, Liangxu Xie, Xiao-Shuang Xu, Yimin Li, Xiaojun Xu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2023-02-01
Serier:Microbiology Spectrum
Fag:
HIV-1 capsid
capsid assembly
hexamer
drug screening
biolayer interferometry
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.02663-22
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