Cinaciguat (BAY-582667) Modifies Cardiopulmonary and Systemic Circulation in Chronically Hypoxic and Pulmonary Hypertensive Neonatal Lambs in the Alto Andino

Neonatal pulmonary hypertension (NPHT) is produced by sustained pulmonary vasoconstriction and increased vascular remodeling. Soluble guanylyl cyclase (sGC) participates in signaling pathways that induce vascular vasodilation and reduce vascular remodeling. However, when sGC is oxidized and/or loses...

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Detalhes bibliográficos

Principais autores:	Felipe A. Beñaldo, Claudio Araya-Quijada, Germán Ebensperger, Emilio A. Herrera, Roberto V. Reyes, Fernando A. Moraga, Alexander Riquelme, Alejandro Gónzalez-Candia, Sebastián Castillo-Galán, Guillermo J. Valenzuela, María Serón-Ferré, Aníbal J. Llanos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-06-01
coleção:	Frontiers in Physiology
Assuntos:	Cinaciguat hypoxia pulmonary hypertension newborn high altitude
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphys.2022.864010/full
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