Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong antioxidant properties and improves pulmonary vascular function. Here, we ai...

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主要な著者:	Cristian R. Astorga, Alejandro González-Candia, Alejandro A. Candia, Esteban G. Figueroa, Daniel Cañas, Germán Ebensperger, Roberto V. Reyes, Aníbal J. Llanos, Emilio A. Herrera
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2018-03-01
シリーズ:	Frontiers in Physiology
主題:	neonatal pulmonary hypertension vascular remodeling hypoxic pulmonary vasoconstriction chronic hypoxia oxidative stress melatonin
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fphys.2018.00185/full
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