Persistent Hypoxia with Intermittent Aggravation Causes Imbalance in Smad3/Myocardin-Related Transcription Factor Signaling with Consequent Endothelial Senescence and Pulmonary Arterial Remodeling

Loss of Smad3 and the consequent activation of myocardin-related transcription factor (MRTF) are associated with vascular pathologies. This study aimed to examine the impact of persistent hypoxia with intermittent aggravation (PI hypoxia) on cellular senescence and pulmonary arterial remodeling medi...

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Hlavní autoři:	Jiaxin Hu, Prachi Singh, Jingrui Li, Jing Zhang, Fei Li, Hehe Zhang, Jiang Xie
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-08-01
Edice:	Biomedicines
Témata:	myocardin-related transcription factor PI hypoxia remodeling senescence Smad3
On-line přístup:	https://www.mdpi.com/2227-9059/11/9/2351
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