Persistent Hypoxia with Intermittent Aggravation Causes Imbalance in Smad3/Myocardin-Related Transcription Factor Signaling with Consequent Endothelial Senescence and Pulmonary Arterial Remodeling

Loss of Smad3 and the consequent activation of myocardin-related transcription factor (MRTF) are associated with vascular pathologies. This study aimed to examine the impact of persistent hypoxia with intermittent aggravation (PI hypoxia) on cellular senescence and pulmonary arterial remodeling medi...

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Hauptverfasser:	Jiaxin Hu, Prachi Singh, Jingrui Li, Jing Zhang, Fei Li, Hehe Zhang, Jiang Xie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-08-01
Schriftenreihe:	Biomedicines
Schlagworte:	myocardin-related transcription factor PI hypoxia remodeling senescence Smad3
Online-Zugang:	https://www.mdpi.com/2227-9059/11/9/2351
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