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Tolerance to the Antinociceptive Effects of Chronic Morphine Requires C-Jun N-Terminal Kinase

Background Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed as a putative mechanism driving tolerance to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: David J. Marcus, Michael Zee, Alex Hughes, Matthew B. Yuill, Andrea G. Hohmann, Ken Mackie, Josée Guindon, Daniel J. Morgan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SAGE Publishing 2015-06-01
Cyfres:Molecular Pain
Mynediad Ar-lein:https://doi.org/10.1186/s12990-015-0031-4
Tagiau: Ychwanegu Tag
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