Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders

Abstract Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology. Here, we report that the robust activation of neurotoxic astrocytes (A1 astrocytes) in the CNS promo...

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Manylion Llyfryddiaeth

Prif Awduron:	Jingxian Lun, Yubin Li, Xuefeng Gao, Zelong Gong, Xiaoliang Chen, Jinhu Zou, Chengxing Zhou, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang, Hong Cao
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2023-03-01
Cyfres:	Journal of Neuroinflammation
Pynciau:	Kynurenic acid HIV-1 gp120 Neurotoxic astrocytes α7nAChR Tryptophan
Mynediad Ar-lein:	https://doi.org/10.1186/s12974-023-02771-4
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!