Human umbilical mesenchymal stem cell-derived mitochondria transplantation suppresses sFLT-1 secretion by regulating calcineurin-NFAT-dependent pathways in angiotensin II-induced preeclampsia rats

Abstract Background Mitochondrial transplantation (Mito-T) is a novel therapeutic strategy for ischaemic cardiovascular diseases. This study aimed to test the efficacy of human umbilical mesenchymal stem cell-derived mitochondrial transplantation (Mito-T) on preeclampsia (PE). Methods PE was induced...

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Detalhes bibliográficos

Principais autores:	Hui Xing Cui, Jun Xian Liu, Young Cheol Kang, Kyuboem Han, Hong Kyu Lee, Chun-Hyung Kim, Yin Hua Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Mitochondrial transplantation Human umbilical mesenchymal stem cell Preeclampsia sFlt-1 PlGF sFlt-1/PlGF
Acesso em linha:	https://doi.org/10.1186/s13287-026-04930-9
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