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Human umbilical mesenchymal stem cell-derived mitochondria transplantation suppresses sFLT-1 secretion by regulating calcineurin-NFAT-dependent pathways in angiotensin II-induced preeclampsia rats

Abstract Background Mitochondrial transplantation (Mito-T) is a novel therapeutic strategy for ischaemic cardiovascular diseases. This study aimed to test the efficacy of human umbilical mesenchymal stem cell-derived mitochondrial transplantation (Mito-T) on preeclampsia (PE). Methods PE was induced...

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Principais autores: Hui Xing Cui, Jun Xian Liu, Young Cheol Kang, Kyuboem Han, Hong Kyu Lee, Chun-Hyung Kim, Yin Hua Zhang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:Stem Cell Research & Therapy
Fag:
Mitochondrial transplantation
Human umbilical mesenchymal stem cell
Preeclampsia
sFlt-1
PlGF
sFlt-1/PlGF
Online adgang:https://doi.org/10.1186/s13287-026-04930-9
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