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Optimizing proton minibeam radiotherapy by interlacing and heterogeneous tumor dose on the basis of calculated clonogenic cell survival

Abstract Proton minibeam radiotherapy (pMBRT) is a spatial fractionation method using sub-millimeter beams at center-to-center (ctc) distances of a few millimeters to widen the therapeutic index by reduction of side effects in normal tissues. Interlaced minibeams from two opposing or four orthogonal...

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Detalhes bibliográficos
Principais autores: Matthias Sammer, Stefanie Girst, Günther Dollinger
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2021-02-01
coleção:Scientific Reports
Acesso em linha:https://doi.org/10.1038/s41598-021-81708-4
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