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Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone

Mitochondrial dysfunction has been implicated in Parkinson's disease (PD) neuropathology. Mic60, also known as mitofilin, is a protein of the inner mitochondrial membrane and a key component of the mitochondrial contact site and cristae junction organizing system (MICOS). Mic60 is critical for maint...

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Principais autores: Victor S. Van Laar, Sarah B. Berman, Teresa G. Hastings
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-07-01
Serier:Neurobiology of Disease
Fag:
Mitofilin
Mic60
Parkinson's disease
Mitochondria
Mitochondrial dynamics
Fission
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996116300596
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