Infusion of Sibling Marrow in a Patient with Purine Nucleoside Phosphorylase Deficiency Leads to Split Mixed Donor Chimerism and Normal Immunity

Purine nucleoside phosphorylase (PNP) deficiency, a rare autosomal recessive metabolic disease causes combined immunodeficiency and developmental delay, hypotonia, and spasticity. Patients present with recurrent infections associated with T-lymphocytopenia, characteristically presenting later than p...

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Bibliografiske detaljer

Principais autores:	Laura Yeates, Mary A. Slatter, Andrew R. Gennery
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2017-06-01
Serier:	Frontiers in Pediatrics
Fag:	purine nucleoside phosphorylase hematopoietic stem cell transplantation sibling donor unconditioned immune reconstitution
Online adgang:	http://journal.frontiersin.org/article/10.3389/fped.2017.00143/full
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