Attenuation of IFITM proteins’ antiviral activity through sequestration into intraluminal vesicles of late endosomes

IntroductionInterferon-induced transmembrane proteins (IFITMs) inhibit the entry of diverse enveloped viruses. The spectrum of antiviral activity of IFITMs is largely determined by their subcellular localization. IFITM1 localizes to and primarily blocks viral fusion at the plasma membrane, while IFI...

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Hauptverfasser:	David Prikryl, You Zhang, Smita Verma, Gregory B. Melikyan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-08-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	IFITM cyclosporine A virus restriction viral fusion super-resolution microscopy endocytosis
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1647166/full
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