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A 7-gene expression signature predicts immune microenvironment remodeling and neoadjuvant chemo-immunotherapy response in lung squamous cell carcinoma

BackgroundNeoadjuvant chemo-immunotherapy (NCI) has significantly improved outcomes in advanced lung squamous cell carcinoma (LUSC). However, some patients remain resistant to NCI, resulting in poor outcomes. The mechanisms behind this resistance remain unclear.MethodsForty LUSC patients receiving N...

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Principais autores: Shaoling Li, Junhong Guo, Yan Huang, Zhengwei Dong, Ranyue Wang, Huifang Liu, Yaoqi Xiao, Jin Wang, Xing Li, Zhan Huang, Tao Hu, Changbin Zhu, Likun Hou, Chunyan Wu
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2026-02-01
Series:Frontiers in Immunology
Assuntos:
HOXC13
lung squamous cell carcinoma
neoadjuvant chemo-immunotherapy
RNA sequencing
tumor microenvironment
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1696792/full
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