The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

Abstract Background Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia results in acute lung injury (ALI) and accumulation...

Descripción completa

Detalles Bibliográficos

Autores principales:	Ravikumar A. Sitapara, Alex G. Gauthier, Sergio I. Valdés-Ferrer, Mosi Lin, Vivek Patel, Mao Wang, Ashley T. Martino, Jeanette C. Perron, Charles R. Ashby, Kevin J. Tracey, Valentin A. Pavlov, Lin L. Mantell
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2020-06-01
Colección:	Molecular Medicine
Materias:	Hyperoxia Lung injury a7nAChR Vagus nerve Cholinergic anti-inflammatory pathway Inflammatory reflex
Acceso en línea:	http://link.springer.com/article/10.1186/s10020-020-00177-z
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!