The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Supplemental oxygen therapy with supraphysiological concentrations of oxygen (hyperoxia; >21% O₂) is a life-saving intervention for patients experiencing respiratory distress. However, prolonged exposure to hyperoxia can compromise bacterial clearance processes, due to oxidative stress-me...

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Detalhes bibliográficos

Principais autores:	Alex G. Gauthier, Jiaqi Wu, Mosi Lin, Ravikumar Sitapara, Abhijit Kulkarni, Ganesh A. Thakur, Edward E. Schmidt, Jeanette C. Perron, Charles R. Ashby, Lin L. Mantell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-01-01
coleção:	Antioxidants
Assuntos:	hyperoxia α7nAChR GAT107 ago-PAM macrophage pulmonary infection
Acesso em linha:	https://www.mdpi.com/2076-3921/10/1/135
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