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The build-up of stock of stable integrated proviruses overtime explains the difficulty in reducing HIV-1 DNA levels when treatment is initiated at the chronic stage of the infection

Background: Understanding factors affecting the size and the evolution of the HIV reservoir is essential for the development of curative strategies. This study aimed to assess the impact of antiretroviral therapy (ART) initiated during primary infection (PHI) vs chronic infection (CHI) on the levels...

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Autori principali: Gilbert Mchantaf, Antoine Cheret, Adeline Melard, Asma Essat, Elise Gardiennet, Rebecca Bauer, Caroline Charre, Vincent Meiffredy, Lionel Piroth, Cécile Goujard, Laurence Meyer, Véronique Avettand-Fenoel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-12-01
Serie:Journal of Virus Eradication
Soggetti:
Integrated HIV-1 DNA
Total HIV-1 DNA
Early ART
Deferred treatment
Reservoir decay
Accesso online:http://www.sciencedirect.com/science/article/pii/S2055664023000432
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