Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model.

Most cancer-specific antigens used as targets of antibody-drug conjugates and immunotoxins are shed from the cell surface (Zhang & Pastan (2008) Clin. Cancer Res. 14: 7981-7986), although at widely varying rates and by different mechanisms (Dello Sbarba & Rovida (2002) Biol. Chem. 383: 69-83). Why m...

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Hlavní autoři:	Youngshang Pak, Ira Pastan, Robert J Kreitman, Byungkook Lee
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2014-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC4208831?pdf=render
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