Pomegranate peel extract alleviates diabetic retinopathy by suppressing the PI3K/AKT/HIF-1α/VEGF pathway and gut microbiota modulation

Introduction: Diabetic retinopathy (DR) is a severe microvascular complication of diabetes mellitus. Pomegranate peel extract (PPE) has shown potential in mitigating various diabetic complications, yet its role in DR remains unexplored. Objective: To investigate the beneficial effects and underlying...

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Bibliographic Details

Main Authors:	Qi-dong Ren, Mei-rong Li, Mohamed A. Farag, Lin-lin Qiu, Yan-ao Wang, Dan Liu, Hao-ran Liu, Jin-yue Sun, Ning-yang Li, Chao Liu
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2026-07-01
Series:	Journal of Advanced Research
Subjects:	Pomegranate peel Diabetic retinopathy Retinal pigment epithelium PI3K/AKT HIF-1α/VEGF gut microbiota
Online Access:	http://www.sciencedirect.com/science/article/pii/S2090123225008434
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