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Pomegranate peel extract alleviates diabetic retinopathy by suppressing the PI3K/AKT/HIF-1α/VEGF pathway and gut microbiota modulation

Introduction: Diabetic retinopathy (DR) is a severe microvascular complication of diabetes mellitus. Pomegranate peel extract (PPE) has shown potential in mitigating various diabetic complications, yet its role in DR remains unexplored. Objective: To investigate the beneficial effects and underlying...

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Principais autores: Qi-dong Ren, Mei-rong Li, Mohamed A. Farag, Lin-lin Qiu, Yan-ao Wang, Dan Liu, Hao-ran Liu, Jin-yue Sun, Ning-yang Li, Chao Liu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-07-01
Serier:Journal of Advanced Research
Fag:
Pomegranate peel
Diabetic retinopathy
Retinal pigment epithelium
PI3K/AKT
HIF-1α/VEGF
gut microbiota
Online adgang:http://www.sciencedirect.com/science/article/pii/S2090123225008434
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