Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

CDC42 controls intestinal epithelial (IEC) stem cell (IESC) division. How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear. We utilized models of inflammatory bowel diseases (IBD), colorectal cancer, aging, and IESC injury to determine the loss of intestinal Cdc42 upon inflam...

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Autors principals:	Dongsheng Zhang, Wenjuan Tang, Haitao Niu, William Tse, Hai-Bin Ruan, Helmut Dolznig, Thomas Knösel, Friedrich Karl-Heinz, Madeleine Themanns, Jiang Wang, Mingquan Song, Lee Denson, Lukas Kenner, Richard Moriggl, Yi Zheng, Xiaonan Han
Format:	Artigo
Idioma:	Inglês
Publicat:	KeAi Communications Co., Ltd. 2024-01-01
Col·lecció:	Genes and Diseases
Matèries:	Cell division cycle 42 (CDC42) Colitis Colorectal cancer (CRC) Inflammatory bowel diseases (IBD) Intestinal epithelial cell (IEC) Intestinal epithelial stem cell (IESC)
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2352304222003300
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