APOE-mediated lipid transport prevents C1q-related synaptic loss after spinal cord injury via attenuating macrophage lipid stress

Abstract Following spinal cord injury (SCI), neuroinflammation driven by lipid-laden macrophage foam cells is a key pathology, yet how these cells manage their lipid homeostasis is unclear. We delineate a neuroprotective axis in which macrophages deploy apolipoprotein E (APOE) to transfer intracellu...

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Autori principali:	Yersen Mulat, Zun Ren, Chaocao Nong, Chuanliang Fu, Yilin Huo, Mai Zhao, Yahui Dai, Canyu Chen, Peilin Wang, Renyuan Wang, Hao Zhang, Yi Hu, Peng Lai, Ruoyi Guo, Dongsheng Jiang, Ying Peng, Haodong Lin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-03-01
Serie:	Journal of Neuroinflammation
Accesso online:	https://doi.org/10.1186/s12974-026-03756-9
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