Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord

Abstract Spinal cord injury (SCI) results in significant neurological deficits, and curative therapies are lacking. Neural progenitor cell (NPC) transplantation shows promise, as graft-derived neurons (GDNs) can integrate into host spinal cord and support axon regeneration. Here, we examined the syn...

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Autori principali:	Ashley Tucker, Angelina Baltazar, Jaclyn T. Eisdorfer, Joshua K. Thackray, Katie Vo, Hannah Thomas, Avnika Tandon, Joshua Moses, Brendan Singletary, Tucker Gillespie, Ashley Smith, Anna Pauken, Sneha Nadella, Michael Pitonak, Sunjay Letchuman, Julius Jang, Michael Totty, Frank L. Jalufka, Miriam Aceves, Andrew F. Adler, Stephen Maren, Heath Blackmon, Dylan A. McCreedy, Victoria Abraira, Jennifer N. Dulin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-11-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-025-65395-7
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