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Interplay between microbial‐derived GABA and host GABA receptor signaling collectively influence the tumorigenic function of GABA in colon cancer

Abstract Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome represents another potential source of GABA. Both GABAA and GABAB receptors have been implicated in contributing to the effects of G...

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Principais autores: Jonathan M. Keane, Philana Fernandes, Florian Kratz, Grace O'Callaghan, Cormac G. M. Gahan, Susan A. Joyce, Catherine Stanton, Niall P. Hyland, Aileen Houston
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2024-08-01
Serier:Pharmacology Research & Perspectives
Fag:
colon tumorigenesis
gamma‐aminobutyric acid
glutamate decarboxylase
inflammation
microbiome
proliferation
Online adgang:https://doi.org/10.1002/prp2.1226
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