Interplay between microbial‐derived GABA and host GABA receptor signaling collectively influence the tumorigenic function of GABA in colon cancer

Abstract Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome represents another potential source of GABA. Both GABAA and GABAB receptors have been implicated in contributing to the effects of G...

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Ngā kaituhi matua:	Jonathan M. Keane, Philana Fernandes, Florian Kratz, Grace O'Callaghan, Cormac G. M. Gahan, Susan A. Joyce, Catherine Stanton, Niall P. Hyland, Aileen Houston
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2024-08-01
Rangatū:	Pharmacology Research & Perspectives
Ngā marau:	colon tumorigenesis gamma‐aminobutyric acid glutamate decarboxylase inflammation microbiome proliferation
Urunga tuihono:	https://doi.org/10.1002/prp2.1226
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!