Class IA PI3K isoforms lead to differential signalling downstream of PKB/Akt

The catalytic subunits of Class IA PI3K, p110α, p110β, and p110δ, phosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) into phosphatidylinositol 3,4,5-trisphosphate (PIP3) on the plasma membrane. In cancer, these catalytic subunits are usually found to be altered or amplified. Because pan-PI3...

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Autors principals:	Catalak Yilmaz Hazal B., Sulaiman Mahnoor, Isik Ozlem Aybuke, Cizmecioglu Onur
Format:	Artigo
Idioma:	Inglês
Publicat:	De Gruyter 2023-12-01
Col·lecció:	Türk Biyokimya Dergisi
Matèries:	phosphoinositide 3-kinase protein kinase b mammalian target of rapamycin (mtor) cell cycle cytotoxicity
Accés en línia:	https://doi.org/10.1515/tjb-2023-0146
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